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rabbit polyclonal anti ho1  (Danaher Inc)


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    Structured Review

    Danaher Inc rabbit polyclonal anti ho1
    A schematic illustration of potential <t>CFTR-Nrf2-HO1/NQO1</t> pathways that might mitigate gentamicin-induced hearing loss. Gentamicin causes accumulation of ROS in cochlear hair cells, resulting in oxidative stress imbalance and ultimately hair cell death. Ivacaftor plays an antioxidant role by activating the CFTR-Nrf2-HO1/NQO1 axis to protect sensory hair cells.
    Rabbit Polyclonal Anti Ho1, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rabbit+polyclonal+anti+ho1/pmc10993751-59-22-26
    Average 86 stars, based on 1 article reviews
    rabbit polyclonal anti ho1 - by Bioz Stars, 2026-09
    86/100 stars

    Images

    1) Product Images from "Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway"

    Article Title: Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway

    Journal: Redox Report : Communications in Free Radical Research

    doi: 10.1080/13510002.2024.2332038

    A schematic illustration of potential CFTR-Nrf2-HO1/NQO1 pathways that might mitigate gentamicin-induced hearing loss. Gentamicin causes accumulation of ROS in cochlear hair cells, resulting in oxidative stress imbalance and ultimately hair cell death. Ivacaftor plays an antioxidant role by activating the CFTR-Nrf2-HO1/NQO1 axis to protect sensory hair cells.
    Figure Legend Snippet: A schematic illustration of potential CFTR-Nrf2-HO1/NQO1 pathways that might mitigate gentamicin-induced hearing loss. Gentamicin causes accumulation of ROS in cochlear hair cells, resulting in oxidative stress imbalance and ultimately hair cell death. Ivacaftor plays an antioxidant role by activating the CFTR-Nrf2-HO1/NQO1 axis to protect sensory hair cells.

    Techniques Used:

    Related Articles

    Western Blot:

    Article Title: Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway
    Article Snippet: Total protein was extracted with RIPA lysis buffer (CW2333, CWBIO, CN) with 1x Protease Inhibitor Cocktail (CW2000, CWBIO, CN). .. The primary antibodies used for western blot were as follows: mouse monoclonal anti-CFTR (66928-1-Ig, Proteintech, CN), Rabbit polyclonal anti-Nrf2 (16396-1-AP, Proteintech, CN), rabbit polyclonal anti-HO1 (ab52947, Abcam, USA), NQO1 (ab80588, Abcam, USA), SOD2 (66474-1-Ig, Proteintech, CN), and Keap1 (10503-2-AP, Proteintech, CN), anti-Cleaved Caspase 3 (25128-1-AP, Proteintech, CN), anti-beta actin (66009-1-Ig, Proteintech, CN), anti-Laminb1 (66095-1-Ig, Proteintech, CN), anti-GAPDH (10494-1-AP, Proteintech, CN). ..

    Expressing:

    Article Title: Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety
    Article Snippet: .. Mouse tissue sections were analyzed for 8OHdG and expression of NRF2, NAD(P)H dehydrogenase [quinone] 1 (NQO1), heme oxygenase 1 (HO1), metallothionein 1 (MT1), and glutamate-cysteine ligase, catalytic subunit (GCLC) by IHC with the following antibodies overnight at 4C: a rabbit polyclonal anti-8-OHdG antibody (1:8000; Abcam), a rabbit polyclonal anti-NRF2 (1:200) [ ], a rabbit polyclonal anti-NQO1 antibody (1:8000; Abcam), a mouse monoclonal anti-MT1 (1:100; Accurate Chemical & Scientific, Westbury, NY), a rabbit polyclonal anti-HO1 (1:25; Abcam), and a rabbit polyclonal anti-GCLC (1:100; LifeSpan BioSciences, Seattle, WA). ..

    Immunohistochemistry:

    Article Title: Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety
    Article Snippet: .. Mouse tissue sections were analyzed for 8OHdG and expression of NRF2, NAD(P)H dehydrogenase [quinone] 1 (NQO1), heme oxygenase 1 (HO1), metallothionein 1 (MT1), and glutamate-cysteine ligase, catalytic subunit (GCLC) by IHC with the following antibodies overnight at 4C: a rabbit polyclonal anti-8-OHdG antibody (1:8000; Abcam), a rabbit polyclonal anti-NRF2 (1:200) [ ], a rabbit polyclonal anti-NQO1 antibody (1:8000; Abcam), a mouse monoclonal anti-MT1 (1:100; Accurate Chemical & Scientific, Westbury, NY), a rabbit polyclonal anti-HO1 (1:25; Abcam), and a rabbit polyclonal anti-GCLC (1:100; LifeSpan BioSciences, Seattle, WA). ..



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    A schematic illustration of potential <t>CFTR-Nrf2-HO1/NQO1</t> pathways that might mitigate gentamicin-induced hearing loss. Gentamicin causes accumulation of ROS in cochlear hair cells, resulting in oxidative stress imbalance and ultimately hair cell death. Ivacaftor plays an antioxidant role by activating the CFTR-Nrf2-HO1/NQO1 axis to protect sensory hair cells.
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    Image Search Results


    A schematic illustration of potential CFTR-Nrf2-HO1/NQO1 pathways that might mitigate gentamicin-induced hearing loss. Gentamicin causes accumulation of ROS in cochlear hair cells, resulting in oxidative stress imbalance and ultimately hair cell death. Ivacaftor plays an antioxidant role by activating the CFTR-Nrf2-HO1/NQO1 axis to protect sensory hair cells.

    Journal: Redox Report : Communications in Free Radical Research

    Article Title: Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway

    doi: 10.1080/13510002.2024.2332038

    Figure Lengend Snippet: A schematic illustration of potential CFTR-Nrf2-HO1/NQO1 pathways that might mitigate gentamicin-induced hearing loss. Gentamicin causes accumulation of ROS in cochlear hair cells, resulting in oxidative stress imbalance and ultimately hair cell death. Ivacaftor plays an antioxidant role by activating the CFTR-Nrf2-HO1/NQO1 axis to protect sensory hair cells.

    Article Snippet: The primary antibodies used for western blot were as follows: mouse monoclonal anti-CFTR (66928-1-Ig, Proteintech, CN), Rabbit polyclonal anti-Nrf2 (16396-1-AP, Proteintech, CN), rabbit polyclonal anti-HO1 (ab52947, Abcam, USA), NQO1 (ab80588, Abcam, USA), SOD2 (66474-1-Ig, Proteintech, CN), and Keap1 (10503-2-AP, Proteintech, CN), anti-Cleaved Caspase 3 (25128-1-AP, Proteintech, CN), anti-beta actin (66009-1-Ig, Proteintech, CN), anti-Laminb1 (66095-1-Ig, Proteintech, CN), anti-GAPDH (10494-1-AP, Proteintech, CN).

    Techniques: